# STRUCTURE & FUNCTION OF THE GENOMES OF SMALL VIRUSES

> **NIH NIH R01** · UNIVERSITY OF WISCONSIN-MADISON · 1987 · $136,936

## Abstract

The purpose of this work is to modify the genomes of the mRNA
viruses BMV (brome mosaic virus), Q beta bacteriophage and
SBMV (southern bean mosaic virus) and their relatives in order to
study the fundamental processes of viral genome replication, viral
protein synthesis, virion assembly and their interrelationships.
The immediate goals in making these modifications are both to
alter virus-host interactions and to enable the construction of
vectors for the introduction of new or alternative viral functions.
Constructions will be made in which viral cDNAs and their RNA
transcripts are intermediates in the infectious process in order to
use the powerful techniques of recombinant DNA chemistry.
Modifications will be introduced to further identify the proteins
encoded in viral genomes and delineate their mechanism of action
and to identify and characterize genomic regulatory sites.

## Key facts

- **NIH application ID:** 3124080
- **Project number:** 2R01AI001466-31
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **SAM.gov UEI:** LCLSJAGTNZQ7
- **Principal Investigator:** PAUL J KAESBERG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $136,936
- **Award type:** 2
- **Project period:** 1977-03-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124080

## Citation

> US National Institutes of Health, RePORTER application 3124080, STRUCTURE & FUNCTION OF THE GENOMES OF SMALL VIRUSES (2R01AI001466-31). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124080. Licensed CC0.

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