# ANTIBODY FORMATION BY LYMPHOID CELLS

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 1987 · $168,948

## Abstract

Immune responses involving T lymphocytes are of major importance in
determining the fate of organ grafts, the outcome of many virus infections,
and probably the response to tumors as well.  T lymphocytes react with
antigens in each of these situations through antigen-specific cell surface
receptors.  Although a considerable body of evidence indicates that the T
cell receptor shares idiotypic determinants with those found on
immunoglobolin and that there is genetic linkage between the T cell
receptor and the immunoglobulin heavy chain allotype, this important cell
receptor has remained elusive.  With the development of cloned T cells and
antibody-producing hybridoma technology, it is now possible to obtain
homogeneous T cells and monoclonal antibodies.  We will use these materials
to characterize the antigen receptor of cytolytic T lymphocytes (CTL).  We
have obtained a "clone-specific" monoclonal antibody, and we will develop
additional monoclonal "clone-specific" antibodies which inhibit the
antigen-related functions of cloned CTL.  Such antibodies are likely
candidates for antibodies reactive with the T cell receptor for antigen.
We also will develop monoclonal antibodies reactive with CTL alloantigens
("IgT-CCTL") which are linked with immunoglobulin (Ig) heavy chain
allotypes.  Such antibodies are likely candidates for antibodies reactive
with "constant region" markers on the T cell receptor.  The
"clone-specific" and "IgT-CCTL" antibodies and the CTL with which they
react will be used in collaborative studies with Dr. Susumu Tonegawa to
identify and characterize genes coding for the antigen receptors of
cytolytic T cells.  We also will try to determine whether CTL and
antibodies reactive with the same alloantigenic epitope bear the same
idiotype.  The ultimate objectives of the proposed studies are to gain a
better understanding of the functional characteristics of the T cell
receptor for antigen and to develop more specific, rational, and effective
means to manipulate specific immune responses.  Although mice are being
used in these studies, we feel that the information obtained may be
applicable ultimately in human situations.

## Key facts

- **NIH application ID:** 3124185
- **Project number:** 5R01AI004197-26
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **SAM.gov UEI:** ZUE9HKT2CLC9
- **Principal Investigator:** FRANK W. FITCH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $168,948
- **Award type:** 5
- **Project period:** 1978-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124185

## Citation

> US National Institutes of Health, RePORTER application 3124185, ANTIBODY FORMATION BY LYMPHOID CELLS (5R01AI004197-26). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124185. Licensed CC0.

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