# STRUCTURES OF ANTIBIOTICS AND RELATED COMPOUNDS

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 1990 · $294,621

## Abstract

Compounds with antiviral, antineoplastic, immunomodulatory, antifungal, and
antibacterial activities will be identified in marine species and their
structures will be assigned.  These include antineoplastic compounds from
Ecteinascidia turbinata and new components of the didemnin (antiviral,
antineoplastic, immunosuppressive) complex from Trididemnum solidum, as
well as compounds from other tunicates, sponges, and algae.  Bioassays to
be employed in identifying active extracts and isolated compounds include
tests against Herpes simplex virus, type I, Vesicular stomatitis virus,
visna virus, and HIV-1; reverse transcriptase; cytotoxicity assays with
L1210 murine leukemia and CV-1 monkey kidney cells; brine shrimp assay and
Agrobacterium tumefaciens potato tumor assay; B-cell and T-cell mitogenesis
inhibition, mixed lymphocyte reaction; and antimicrobial assays against
Bacillus subtilis, Micrococcus luteus, Escherichia coli, Saccharomyces
cerevisiae, and Penicillium atrovenetum.

Compounds with antiviral, immunomodulatory, and cytotoxic activities will
also be sought and identified in extensive collections of cyanobacteria
(blue-green algae), insects, and plant species.  Structures of the
antifungal polyene antibiotics hamycin and aureofungin will also be
studied.

In addition, structural studies will be carried out on pretunichlorins,
unique nickel-containing chlorins from T. solidum, on hepatotoxins from
cyanobacteria, on iron-transport hydroxamates from Hemophilus influenzae,
and on a hibernation- and fasting-characteristic compound produced by black
bears and humans.

## Key facts

- **NIH application ID:** 3124201
- **Project number:** 2R01AI004769-29
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **SAM.gov UEI:** Y8CWNJRCNN91
- **Principal Investigator:** KENNETH L RINEHART
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $294,621
- **Award type:** 2
- **Project period:** 1977-05-01 → 1995-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124201

## Citation

> US National Institutes of Health, RePORTER application 3124201, STRUCTURES OF ANTIBIOTICS AND RELATED COMPOUNDS (2R01AI004769-29). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124201. Licensed CC0.

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