# STRUCTURES OF ANTIBIOTICS AND RELATED COMPOUNDS

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 1989 · $250,953

## Abstract

Compounds with antiviral, antineoplastic, antifungal and antibacterial
activities will be identified in marine species and their structures will
be assigned.  These include new components of the didemnin (antiviral,
antineoplastic) and eudistomin (antiviral) complexes and an antineoplastic
compound from Ecteinascidia turbinata, all from tunicates, as well as
compounds from other tunicates and sponges.  In addition, metabolites and
quantitation of didemnin B will be studied in connection with its
forthcoming clinical trials in cancer patients.

Structures of a number of antibiotics will also be studied.  These include
the antifungal polyenes hamycin, aureofungin, and candimycin, as well as
the non-polyenic antifungal macrolide desertomycin, the phospholipids
quebemycin and 409 complex (antibacterial), the aromatic crisamicin
(antineoplastic), and ficellomycin.  Peptide antibiotics to be studied
include saramycetin (antifungal), CC-1014B (cytotoxic), berninamycins A and
B (antibacterial), antiamoebin, emerimicin, zervamicin, and alamethicin
(all antibacterial and pore-forming).

Bioactive compounds (antiviral) present in insects will also be identified
and structural studies will be carried out on a Legionella pigment and a
Pseudomonas growth factor.

## Key facts

- **NIH application ID:** 3124205
- **Project number:** 5R01AI004769-28
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **SAM.gov UEI:** Y8CWNJRCNN91
- **Principal Investigator:** KENNETH L RINEHART
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $250,953
- **Award type:** 5
- **Project period:** 1977-05-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124205

## Citation

> US National Institutes of Health, RePORTER application 3124205, STRUCTURES OF ANTIBIOTICS AND RELATED COMPOUNDS (5R01AI004769-28). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124205. Licensed CC0.

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