# LIPIDS OF LEISHMANIAS AND TRYPANOSOMES

> **NIH NIH R01** · UPSTATE MEDICAL UNIVERSITY · 1987 · $100,910

## Abstract

The long term objective of this project is to identify and to study novel
chemotherapeutic approaches to the control of leishmanial and trypanosmal
infections of substantial medical importance, by exploiting new knowledge
that aspects of the lipid biochemistry of the responsible trypanosomatid
flagellates are characteristic of fungi and not of vertebrates.  The
immediate specific aims to realize this objective are to investigate:  a)
the normal sterol metabolism of the life-cycle stages of representative
species of Leishmania and Trypanosoma, b) the perturbations of that
metabolism, and impairment of growth, caused by hypercholesterolemic and
other cytotoxic drugs, and c) the mechanisms of action of the most
effective of those drugs.  Life-cycle stages are to be cultured in vitro,
exposed to drugs, and the consequences to growth and to lipid metabolism
assessed by population enumeration, and by lipid analysis employing
chromatographic (CC, TLC, HPLC, GLC), spectrometric (GC/MS, 1H and 13C NMR,
UV/VIS, FTIR), and radio- and stable isotopic tracer methodologies.

## Key facts

- **NIH application ID:** 3124259
- **Project number:** 5R01AI005802-23
- **Recipient organization:** UPSTATE MEDICAL UNIVERSITY
- **SAM.gov UEI:** HYN3WD58HNN7
- **Principal Investigator:** GEORGE G. HOLZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $100,910
- **Award type:** 5
- **Project period:** 1979-04-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124259

## Citation

> US National Institutes of Health, RePORTER application 3124259, LIPIDS OF LEISHMANIAS AND TRYPANOSOMES (5R01AI005802-23). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124259. Licensed CC0.

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