# LATENCY IN HERPESVIRUS INFECTIONS OF CELLS AND TISSUES

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 1988 · $400,279

## Abstract

A series of variants of HSV which have altered patterns of pathogenesis in
experimental animal systems have been identified.  Examples include:  1)
HSV-I and II intertypic recombinants (RE6 and RS6) which are
non-neurovirulent when injected into adult mouse brains.  2) A strain of
HSV-I (KOS) which is nonvirulent in mice when injected in foot pads.  3) A
revertant of a ts mutant of HSV-I (tsI) which is not temperature sensitive
for replication in non-nervous tissues, but which does not reactivate from
the latent state in spinal ganglia at 38.50C.  In addition, the inability
of HSV-I to invade mesoderm in the CAM of embryonic chicks is being
investigated.  In all cases, trivial explanations for the altered
pathogenicity have been rigorously excluded.  Data are presented
demonstrating that pathogenesis can be rescued using DNA transfections of
wild-type parental DNA restriction fragments (molecularly cloned) and
intact variant virus DNA followed by selection in vivo.  A combined
collaborative study of the genes and gene products involved in these and
related examples of HSV pathology and neurovirulence using techniques of
both molecular biology and pathobiology is described.

## Key facts

- **NIH application ID:** 3124279
- **Project number:** 5R01AI006246-24
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **SAM.gov UEI:** RN64EPNH8JC6
- **Principal Investigator:** JACK G STEVENS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $400,279
- **Award type:** 5
- **Project period:** 1978-11-01 → 1990-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124279

## Citation

> US National Institutes of Health, RePORTER application 3124279, LATENCY IN HERPESVIRUS INFECTIONS OF CELLS AND TISSUES (5R01AI006246-24). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124279. Licensed CC0.

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