# STUDIES OF CELLULAR RESISTANCE TO VIRUS INFECTIONS

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1987 · $224,512

## Abstract

The studies that are planned are directed toward the understanding of the
mechanism of persistent viral infection in cell culture model systems using
vesicular stomatitis, influenza type A, and Newcastle disease viruses.
Special emphasis will be placed on analysis of the evolution of virus and
host cells during long-term persistent infections.  The information
obtained may have pertinence to human illnesses which involve persistent
viral infections.  The importance of such diseases is being increasingly
recognized.

Investigations will be continued dealing with the mechanism of action of
interferon.  Particular emphasis will be placed on characterization of an
effect of interferon recently discovered in this laboratory, namely,
inhibition of cellular endocytosis and virus uptake.  This effect of
interferon is potentially relevant to the use of interferon as an antiviral
and antitumor agent.  In addition, the first example of a virus activity
which can overcome an interferon-induced function (i.e., double-stranded
RNA-dependent protein kinase) will be investigated and characterized.
Besides evaluating the role of the interferon-induced protein kinase in
interferon-mediated restriction of viral protein synthesis, these studies
may provide insight into the mechanism of eukaryotic protein synthesis and
its alteration by virus infection.

The mechanism of virus-mediated inhibition of endocytosis and
superinfection exclusion will be further investigated.  These studies will
yield valuable information concerning the influence of viral infection on
host cell plasma membrane function and on the mechanism of entry of virus
into cells.

## Key facts

- **NIH application ID:** 3124288
- **Project number:** 5R01AI006264-24
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **SAM.gov UEI:** MKAGLD59JRL1
- **Principal Investigator:** JULIUS S YOUNGNER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $224,512
- **Award type:** 5
- **Project period:** 1974-09-01 → 1989-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124288

## Citation

> US National Institutes of Health, RePORTER application 3124288, STUDIES OF CELLULAR RESISTANCE TO VIRUS INFECTIONS (5R01AI006264-24). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124288. Licensed CC0.

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