# HISTOCOMPATIBILITY ANTIGENS

> **NIH NIH R01** · COLUMBUS HOSPITAL (GREAT FALLS, MT) · 1988 · $20,900

## Abstract

The long term objective of this project has been the investigation of
cellular alloantigen systems of the mouse with particular emphasis on the
major histocompatibility gene complex (MHC).  The demonstration that the
MHC plays a key part in the regulation of immune responses and the
observation that humans share a closely related system with mice lends
clinical relevance to the investigation of the MHC.  The MHC is a
genetically regulated system controlled by a cluster of closely-linked
genes.  A goal of the project is to analyze the fine genetic structure of
the MHC using genetic and immunological procedures, to identify and
characterize the structural and functional properties of the component
parts of the MHC and to investigate the manner in which the components of
the MHC regulate immune responsiveness.  Much has been learned about the
mechanics of the immune response through the use of selectively bred
strains of mice which are genetically closely related except for defined
differences within the MHC.

Other experiments are planned which involve the study of the immunogenetic
properties of H-3, a minor histocompatibility locus which can evoke skin
graft rejections.  It is of particular interest because it may be regulated
by a complex gene system.  It will be investigated using immunogenetic
procedures.

## Key facts

- **NIH application ID:** 3124294
- **Project number:** 3R01AI006525-23S1
- **Recipient organization:** COLUMBUS HOSPITAL (GREAT FALLS, MT)
- **Principal Investigator:** JACK H STIMPFLING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $20,900
- **Award type:** 3
- **Project period:** 1975-01-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124294

## Citation

> US National Institutes of Health, RePORTER application 3124294, HISTOCOMPATIBILITY ANTIGENS (3R01AI006525-23S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124294. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*