# HOST REACTIONS TO MICROORGANISMS IN CHRONIC DISEASE

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 1988 · $111,559

## Abstract

The study of phagocytic cell function in patients with susceptibility to serious
bacterial infections will continue.  The observation that peripheral blood
monocytes from patients with cystic fibrosis have increased oxidative metabolism
(measured by chemiluminescence) has led to increased emphasis on studies of this
patient group.  Preliminary studies suggest that chemiluminescence of monocytes
stimulated by adherence to glass surfaces may be a method for detecting the
carrier state in cystic fibrosis.

The observations reported in this year's progress report on the effect of
influenzae virus on metabolic responsiveness of human neutrophils and monocytes
to particulate and non-particulate stimuli has prompted increased effort in
studies on viral-phagocytic cell interaction.  The planned studies include
incubation of cytomegalovirus with neutrophils and monocytes.  These studies
will include observations on phagocytic cell function in animals with
experimental viral infections.

## Key facts

- **NIH application ID:** 3124316
- **Project number:** 5R01AI006931-22
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **SAM.gov UEI:** KABJZBBJ4B54
- **Principal Investigator:** PAUL G QUIE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $111,559
- **Award type:** 5
- **Project period:** 1978-07-01 → 1989-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124316

## Citation

> US National Institutes of Health, RePORTER application 3124316, HOST REACTIONS TO MICROORGANISMS IN CHRONIC DISEASE (5R01AI006931-22). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124316. Licensed CC0.

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