# PHYSICAL CHEMISTRY OF VIRUSES AND THEIR COMPONENTS

> **NIH NIH R01** · PUBLIC HEALTH RESEARCH INSTITUTE · 1987 · $235,769

## Abstract

We propose structural studies on most available filamentous bacterial
viruses, on their intracellular precursor complexes between DNA binding
proteins and progeny DNAs, and on the genomes of some.  All of the viruses
have Gram-negative bacteria as hosts, several of which are pathogenic
either in plants or animals.  All of the viruses have the same basic
overall morphology and all contain a single-stranded DNA genome packed in a
sheath of thousands of identical subunits.  Techniques such as
ultracentrifugation, electron microscopy, light scattering, CD and
fluorescence spectroscopy, X-ray diffraction, and other techniques will be
applied to determine fundamental structure parameters.  Studies on
interactions, between intact virions between various virion components, and
between the DNA binding proteins and nucleic acids are also proposed.  The
amino acid sequences of the major structural proteins are to be established
through DNA sequencing and protein sequencing techniques.  Theoretical work
will be directed toward unified theories of the structures of these
similar, but in detail diverse, nucleoproteins having the same function,
and toward understanding of their evolutionary relationships.

## Key facts

- **NIH application ID:** 3124487
- **Project number:** 5R01AI009049-19
- **Recipient organization:** PUBLIC HEALTH RESEARCH INSTITUTE
- **Principal Investigator:** LOREN A DAY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $235,769
- **Award type:** 5
- **Project period:** 1978-07-01 → 1988-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124487

## Citation

> US National Institutes of Health, RePORTER application 3124487, PHYSICAL CHEMISTRY OF VIRUSES AND THEIR COMPONENTS (5R01AI009049-19). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124487. Licensed CC0.

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