# NORMAL AND NEOPLASTIC T AND B LYMPHOCYTE MATURATION

> **NIH NIH R01** · STANFORD UNIVERSITY · 1988 · $332,234

## Abstract

The major three themes in this grant application are:  1) the elucidation
of lymphocyte homing receptors governing their traffic to organized
lymphoid organs and to sites of immune reaction; 2) the definition of
maturational lineages of thymic and T lymphocytes; and 3) the definition of
maturational lineages of peripveral B and bone marrow pre-B lymphocytes.
The major methods of analysis include the isolation of particular subsets
of cells at defined stages of maturation both in vivo and in vitro, the
analysis of their movement from one stage of maturation to another using
well defined markers, and the production of monoclonal antibodies to cells
at these defined stages of maturation for phenotypic and functional
analyses.  The analysis of lymphocyte homing should lead to an
understanding of what governs lymphocyte cell-cell interactions necessary
for the generation of appropriate (and inappropriate) immune responses
resulting from the movement of lymphoid cells into sites occupied by
exogenous infectious agents, or autologous determinants in autoimmune
disease.  The definition of the interaction between lymphocytes and blood
vessels within lymphoid organs could also lead to an understanding of
various pseudolymphomatous syndromes (for example, angioimmunoblastic
lymphadenopathy), or may yet reveal a previously poorly understood
congenital or acquired immunodeficiency disease.  The analysis of T
lymphocyte development is clearly important both for understanding central
questions in developmental biology and T cell function, but also should be
the key to understanding how T cell deficiency in hypersensitivity diseases
arise.  The current epidemic of acquired immunodeficiency syndrome is, in
fact, the result of elimination of and/or developmental arrest of cells
generally defined as helper T cells.  Similarly, defining B cell lineage
maturation pathways in both antigen independent and antigen dependent sites
should lead to an understanding of developmental defects leading to the
congenital and acquired agammaglobulinemias, and also the stages at which B
cells gain the ability to respond to non-self, but (usually) not to self.
Thus these experiments could lead to an understanding of both
immunodeficiency and hypersensitivity diseases.

## Key facts

- **NIH application ID:** 3124491
- **Project number:** 5R01AI009072-20
- **Recipient organization:** STANFORD UNIVERSITY
- **SAM.gov UEI:** HJD6G4D6TJY5
- **Principal Investigator:** Irving L. Weissman
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $332,234
- **Award type:** 5
- **Project period:** 1975-05-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124491

## Citation

> US National Institutes of Health, RePORTER application 3124491, NORMAL AND NEOPLASTIC T AND B LYMPHOCYTE MATURATION (5R01AI009072-20). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124491. Licensed CC0.

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