# PATHOGENESIS OF DISEASE FROM PERSISTENT VIRAL INFECTION

> **NIH NIH R01** · SCRIPPS CLINIC AND RESEARCH FOUNDATION · 1987 · $55,186

## Abstract

The cause and pathogenesis of tissue injury in most chronic degenerative
diseases of man are unclear, although some of these diseases are clearly
linked with slow or persistent viral infections.  The objective of work
described in this continuation proposal is to study the interactions
between virus, virus infected cells and the immune response in clearing
virus during acute infection or, alternatively, allowing virus to escape
immune surveillance and establish persistent infection.  Specifically,
researc ongoing or planned within this research proposal (1) evaluates the
formation, identification and genetic regulation of virus-antibody immune
complexes in the circulation; (2) establishes cloned cytotoxic T lymphocyte
(CTL) lines in which to identify virus receptors, molecular mechanisms of
membrane lysis, diversity and crossreactivity of CTLs and the structural
relationship between H02 antigens and viral antigens on the plasma membrane
during cytotoxic assult; (3) examines the genetic basis underlying
immunopathologic disease induced by acute and persistent virus infections;
(4) studies virus infection of lymphocytes as a model of persistent
infection and (5) assays the ability of a persistent virus infection to
affect the differentiated ("luxury") function of lymphocytes, i.e., alter
the production of specific antibodies made by hybridomas and abrogate the
lytic activity of CTLs.

## Key facts

- **NIH application ID:** 3124557
- **Project number:** 3R01AI009484-18S1
- **Recipient organization:** SCRIPPS CLINIC AND RESEARCH FOUNDATION
- **Principal Investigator:** MICHAEL B OLDSTONE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $55,186
- **Award type:** 3
- **Project period:** 1987-09-01 → 1987-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124557

## Citation

> US National Institutes of Health, RePORTER application 3124557, PATHOGENESIS OF DISEASE FROM PERSISTENT VIRAL INFECTION (3R01AI009484-18S1). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124557. Licensed CC0.

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