# STRUCTURE-FUNCTION RELATIONSHIP OF IMMUNOGLOBULINS

> **NIH NIH R01** · CYTEL CORPORATION · 1989 · $272,954

## Abstract

The long range goal of this proposal is to study the cell biology and
biochemistry involved in the function of B cells as antigen presenting
cells.  We will focus our attention on two membrane glycoproteins that are
known to be involved in this function, namely membrane immunogloblin and
Ia-antigens.  Furthermore we will attempt to gain information as to why
activation of B cells seems to be important in allowing this cell to serve
as an antigen presenting cell.  As part of this investigation the mechanism
by which Gamma-irradiation inhibits the antigen presenting cell capacity of
these cells will be explored.  We will also try and define other membrane
glycoproteins or elements that might be involved in the antigen presenting
capacity of B cells and in particular to evaluate the potential role of
membrane proteases in the processing of certain antigens.  Among the
techniques that we plan to use to evaluate the role of Ig and membrane Iy
in the antigen presenting capacity of B cells, we will purify these
membrane glycoproteins and incorporate them into liposomes.  These
liposomes will either be utilized directly as antigen presenting units or
they will be used as vehicles to incorporate these membrane molecules into
other cell types in order to probe how they function in different cellular
milieu.

## Key facts

- **NIH application ID:** 3124614
- **Project number:** 5R01AI009758-20
- **Recipient organization:** CYTEL CORPORATION
- **Principal Investigator:** HOWARD M. GREY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $272,954
- **Award type:** 5
- **Project period:** 1975-06-01 → 1990-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124614

## Citation

> US National Institutes of Health, RePORTER application 3124614, STRUCTURE-FUNCTION RELATIONSHIP OF IMMUNOGLOBULINS (5R01AI009758-20). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124614. Licensed CC0.

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