# ALLERGENICITY OF AIRBORNE PARTICULATES

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1987 · $140,373

## Abstract

This project continues an established, multiphasic study of the nature,
levels and human health impact of airborne allergen exposure.  We will
study prevalence patterns of basidiospores, ascospores and selected
imperfect fungi, using microscopy and culture of volumetric collections and
will design and test assay methods based on ELISA inhibition and on
fluorescent staining with monoclonal reagents.  Human Type 1 responses to
previously unstudied spores will be examined by skin and mucosal
provocative tests as well as ELISA and ELISA inhibition.  The latter
aproaches also will be used to study cross reactivity among fungus spore
and pollen types with special emphasis on infrageneric allergen
similarities.  Late reactivity to some basidiospore preparations will be
analyzed using measures of cell-mediated immunity (viz., lymphocyte
transformation, lymphocyte inhibition factor production) as well as of
humoral response (viz., IgE and IgG ELISA, leucocyte histamine release).
The extent of such responses to more commonly recognized fungal agents also
will be examined.

The effectiveness of portable air cleaners for removal of allergenic
particulates will be assessed objectively in replicate treated and
untreated rooms.  In related studies, various protective masking procedures
will be compared for specifically sensitive persons exposed to
animal-derived aerosols; nasal and bronchial patency parameters will be
utilized.

Exposures incident to grass cutting and various turf practices will be
assessed quantitatively by culture, direct microscopy and assay of
amorphous allergens as well as bacterial endotoxins.  Finally, a range of
collection aproaches will be compared to identify relatively low cost
methods for assessing indoor microbial burdens.

## Key facts

- **NIH application ID:** 3124666
- **Project number:** 5R01AI010181-17
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **SAM.gov UEI:** GNJ7BBP73WE9
- **Principal Investigator:** WILLIAM R SOLOMON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $140,373
- **Award type:** 5
- **Project period:** 1977-05-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124666

## Citation

> US National Institutes of Health, RePORTER application 3124666, ALLERGENICITY OF AIRBORNE PARTICULATES (5R01AI010181-17). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3124666. Licensed CC0.

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