# PATHOLOGIC STUDIES OF INFLAMMATION AND IMMUNITY

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 1987 · $206,032

## Abstract

Our ongoing research is concerned with the regulation of immunity by
complementary idiotypes expressed on Igs and B and T cell receptors.  Specific
suppression is produced by immunization of A/He mice with the phosphorylcholine
(Pc) binding IgA myeloma protein secreted by the plasmocytoma HOPC-8 (H8).  Such
actively immunized mice are unresponsive to immunization with Pc containing
antigens.  Conversely, A/He mice actively immunized with Pc are unresponsive to
immunization with H8.  The process of suppression makes tolerant or eliminates
mature B cells of the suppressed clone.  Presumably, specific unresponsiveness
mediated by a prior complementary response must occur in nature and be
disadvantageous to the individual under some circumstances.  If this is so, then
the objective is to devise ways to suppress the prior response and rescue the
suppressed response.

Sublethal irradiation temporarily eliminates mature lymphocytes involved in
suppression.  following irradiation, treatment with antibody of the specificity
produced by the suppressed clone neutralizes remaining complementary antibody or
cells and also tolerizes or eliminates regenerating lymphocytes bearing
comlementary receptors.  In this way the passively given antibody permits
regeneration of the suppressed clone.  Recovery is slow, requiring 1 to 2
months, but is idiotype-specific.  Treatment with irradiation alone or idiotype
alone is totaly ineffective.  The capability for suppressing one response and
then rescuing an autogenous complementary response may be a clinical objective
for treating some autoimmune diseases and cancer.  The present model provides a
conceptual basis for achieving this objective.

## Key facts

- **NIH application ID:** 3124681
- **Project number:** 5R01AI010242-26
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **SAM.gov UEI:** ZUE9HKT2CLC9
- **Principal Investigator:** DONALD A ROWLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $206,032
- **Award type:** 5
- **Project period:** 1978-07-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124681

## Citation

> US National Institutes of Health, RePORTER application 3124681, PATHOLOGIC STUDIES OF INFLAMMATION AND IMMUNITY (5R01AI010242-26). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124681. Licensed CC0.

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