# ELECTRON MICROSCOPY OF PLASMODIUM HOST INTERACTIONS

> **NIH NIH R01** · CASE WESTERN RESERVE UNIVERSITY · 1992 · $127,953

## Abstract

DESCRIPTION (Adapted from the Applicant's Abstract):  The objectives of the
proposed study is to exploit the technology of immunoelectron microscopy to
study various subcellular organelles and their function.  In addition, the
applicant proposes to study the plasmodial heat shock proteins and ookinete
invasion of the mosquito midgut.  The morphological changes of
desferrioximine on the growth and development of malaria parasites will
also be investigated.  The pursuit of these studies will require the
refinement and/or development of suitable immunoelectron microscopic
techniques to prepare plasmodial preparations which retain antigenicity and
ultrastructure.  Such technology is required to study the subcellular
structure and function of parasite specific organelles, as well as the
subcellular localization of various plasmodial proteins such as the heat
shock protein hsp 70 and glucose regulated proteins (grp 75.) In addition
the effect of desferrioximine on in vitro and in vivo derived parasites
will be determined to ascertain its usefulness in the treatment of cerebral
malaria.  The studies are aimed at providing a better understanding of the
host parasite interaction and the subcellular level.

## Key facts

- **NIH application ID:** 3124763
- **Project number:** 5R01AI010645-21
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **SAM.gov UEI:** HJMKEF7EJW69
- **Principal Investigator:** MASAMICHI M AIKAWA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $127,953
- **Award type:** 5
- **Project period:** 1978-09-29 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124763

## Citation

> US National Institutes of Health, RePORTER application 3124763, ELECTRON MICROSCOPY OF PLASMODIUM HOST INTERACTIONS (5R01AI010645-21). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124763. Licensed CC0.

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