# STUDIES OF FC RECEPTORS AND IG BINDING FACTORS

> **NIH NIH R01** · SCRIPPS CLINIC AND RESEARCH FOUNDATION · 1987 · $218,885

## Abstract

The purpose of the research is to determine the structure and function of Fc
receptors foR IgE on lymphocytes and monocytes/macrophages.  1. Lymphocytes of
patients with allergies to pollen will be analyzed for Fc eta receptors (Fc eta
R) positive cells over a year period, before, during and after the grass pollen
season.  The lymphocytes will be cultured and the IgE produced in vitro measured
employing unfractionated and Fc eta R depleted or enriched cells.  2.  Monocytes
will be purified from patients with allergic disease and studied for Fc eta R
positive cells.  It will be determined if phagocytosis of IgE coated target
cells will cause release of slow reacting substance of anaphylaxis (SRS-A) from
monocytes.  3. Rat alveolar and peritoneal macrophages will be analyzed for
their ability to form rosettes with red cells coated with rat myeloma proteins
of all classes and subclasses.  Rat alveolar macrophages were shown to have Fc
eta R and will be tested for release of SRS-A after interaction with aggregated
IgE myeloma proteins.  4. The numbers of Fc eta R positive lymphocytes (both T
and B cells) and macrophages will be determined in rats infected with
Nippostronglyus brasiliensis parasites in various lymphoid organs.  The number
of receptors on these cells will be quantitated by measuring binding of
radiolabeled IgE to isolated cells.

## Key facts

- **NIH application ID:** 3124798
- **Project number:** 5R01AI010734-15
- **Recipient organization:** SCRIPPS CLINIC AND RESEARCH FOUNDATION
- **Principal Investigator:** HANS L SPIEGELBERG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $218,885
- **Award type:** 5
- **Project period:** 1977-01-01 → 1989-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124798

## Citation

> US National Institutes of Health, RePORTER application 3124798, STUDIES OF FC RECEPTORS AND IG BINDING FACTORS (5R01AI010734-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124798. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*