# METABOLISM OF CELLS INFECTED WITH NUCLEAR DNA VIRUSES

> **NIH NIH R01** · VANDERBILT UNIVERSITY · 1989 · $495,194

## Abstract

We shall pursue the following objectives:  1.  Add to our collection of 52
pseudorabies (Pr) virus ts mutants, virus mutants isolated after
mutagenesis of specific regions of the genome.  We shall construct a
complete genetic and physical map of the Pr virus genome.  2.  Study in
detail the interactions of viral DNA molecules within the infected cells in
an attempt to gain an understanding of the processes leading to the two
isomeric orientations of the short unique region of the genome.  3.  Study
the pathways leading to the cleavage of the concatemeric viral DNA and the
assembly of the viral nucleocapsids using ts mutants defective in these
functions.  4.  Study the transcription and processing of immediate-early
(IE) RNA.  The nature of the IE proteins and their functions in terms of
binding to specific regions of the genome or modifying the activity of the
cellular DNA-dependent RNA polymerase II will also be studied.

## Key facts

- **NIH application ID:** 3124855
- **Project number:** 5R01AI010947-18
- **Recipient organization:** VANDERBILT UNIVERSITY
- **SAM.gov UEI:** GTNBNWXJ12D5
- **Principal Investigator:** TAMAR BEN-PORAT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $495,194
- **Award type:** 5
- **Project period:** 1976-01-01 → 1990-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124855

## Citation

> US National Institutes of Health, RePORTER application 3124855, METABOLISM OF CELLS INFECTED WITH NUCLEAR DNA VIRUSES (5R01AI010947-18). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124855. Licensed CC0.

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