# IMMUNOLOGIC RESPONSES TO SCHISTOSOMA MANSONI

> **NIH NIH R01** · VANDERBILT UNIVERSITY · 1993 · $265,896

## Abstract

This proposal will investigate several interrelated immunologic aspects of
the basic host-parasite relationship in the mouse model of schistosomiasis
mansoni.  This important, wide-spread worm infection is prevalent in much
of Africa, the Caribbean and South America.  The long term objective of
this research is to understand sufficiently the balance between host and
parasite to allow manipulation of the system in favor of the host.  These
studies should improve the understanding of cytokine/lymphokine involvement
in the production and immunoregulation of the primary pathogenic mechanism
in murine schistosomiasis the schistosome egg-induced granuloma (Specific
Aim #1).  Specific Aim #2 seeks to define major cross-reactive,
immunoregulatory idiotypes which are expressed on antibodies specific for
schistosome soluble egg antigens (SEA) and elucidate their role in
granuloma modulation at the antibody and T lymphocyte levels.  Examination
of the potential role (s) of gamma/delta (gammadelta+) T cell receptor-
bearing T lymphocytes at different stages and in certain anatomical
locations during schistosomiasis (Specific Aim #3) should yield useful
information about the function of these newly studied cells, and may
clarify previously unstudied aspects of host responsiveness in
schistosomiasis in the dermis, spleen, liver and intestine.  Specific Aim
#4 states, and will explore the validity of, a new hypothesis regarding
differential T cell responses which result in eosinophilopoiesis in
schistosomiasis.  The answers to questions posed in these specific aims
should provide information that will contribute to our fundamental
immunologic knowledge as it applies to schistosomiasis.  When germane, data
and concepts from these studies bay be useful in understanding other
medically important conditions, such as chronic infections, autoimmune
diseases, cancer and transplantation.  These settings parallel
schistosomiasis in the sense that in each the body's immune system must
"learn" to deal with chronic antigenic exposure.

## Key facts

- **NIH application ID:** 3124929
- **Project number:** 5R01AI011289-21
- **Recipient organization:** VANDERBILT UNIVERSITY
- **SAM.gov UEI:** GTNBNWXJ12D5
- **Principal Investigator:** DANIEL G COLLEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $265,896
- **Award type:** 5
- **Project period:** 1976-04-01 → 1995-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124929

## Citation

> US National Institutes of Health, RePORTER application 3124929, IMMUNOLOGIC RESPONSES TO SCHISTOSOMA MANSONI (5R01AI011289-21). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124929. Licensed CC0.

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