# POLYCONDENSED ALICYCLICS AND THEIR ANTIVIRAL ROLE

> **NIH NIH R01** · OHIO STATE UNIVERSITY · 1988 · $167,848

## Abstract

1-Aminoadamantane is known to be a potent antiviral agent.  Its symmetric
shape, lipophilic solubility, and nucleophilic head group are recognized as
responsible for its efficacious behavior toward influenza viruses.  The
goals of this proposal are to develop expedient routes to unusual and
complex spherical hydrocarbons with a view to their proper
functionalization as amino derivatives.  Top priority is to be given to a
more expedient and/or efficient synthesis of the pentagonal dodecahedrane
in order to acquire its -NH-2, -CH2NH2, and -CH-2CH-2NH-2 derivatives for
biological evaluation.  A variety of procedures are described that are
expected to afford these target compounds.  The development of
derivatization chemistry will not stop here, but activity will be suitably
expanded to include bromination and seleneylation (precursors to
dodecahedrane), carbocation generation (means for acquiring otherwise
inaccessible disubstituted derivatives), and ring expansion to
homododecahedranes and the azahomododecahedrane ring system.  Attention
will also be given to the synthesis of tethered dodecahedranes, the
ditrigonal structural isomer, and the larger spherical homologs pentakai-
and hexakaidecahedrane.  Entry to spherical molecules of intermediate size
will also occupy our attention.  These include p-[4-2,5-8]decahedrane,
p-[3-2,5-6]octahedrane and select amino derivatives.  The new synthetic
methodology to be developed promises to be of substantive value in
delineating the degree of ease and rapidity with which spherical molecules
of the above type will become available.

## Key facts

- **NIH application ID:** 3124963
- **Project number:** 5R01AI011490-15
- **Recipient organization:** OHIO STATE UNIVERSITY
- **SAM.gov UEI:** DLWBSLWAJWR1
- **Principal Investigator:** LEO A PAQUETTE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $167,848
- **Award type:** 5
- **Project period:** 1978-05-01 → 1989-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124963

## Citation

> US National Institutes of Health, RePORTER application 3124963, POLYCONDENSED ALICYCLICS AND THEIR ANTIVIRAL ROLE (5R01AI011490-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124963. Licensed CC0.

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