# POLYCONDENSED ALICYCLICS AND THEIR ANTIVIRAL ROLE

> **NIH NIH R01** · OHIO STATE UNIVERSITY · 1991 · $174,304

## Abstract

The principal objectives of the research program outlined herein
are the development of methods for the synthesis of functionalized
and reactive dodeca-hedrane derivatives, clarification of the
mechanisms by which these species react, and systematic structural
variation (where possible) to develop structure-activity
relationships.  In particular, we wish to capitalize on our
observations that while secododecahedryl and homododecahedryl
amines are modestly good antiviral agents, aminododecahedrane
exhibits high toxicity and, in fact, is powerful at inhibiting
leukemia cell lines.  The potential of this class of compounds
makes analysis of their mode of action and clarification of those
structural features responsible for the different activities timely
and important.  No other laboratory in the world is as equipped to
deal with this problem as we are.  Speculation abounds on the
extent and direction of electronic effects capable of operating
within the dodecahedrane sphere.  We hope to provide quantitative
documentation of these phenomena.  Controlled polyfunctionalization
of dodecahedrane needs to be developed.  The new chemistry to be
implemented here should concomitantly make available new amino-
substituted spherical compounds for appropriate bioassay.  In order
to broaden the range of useful chemical reactions, it is imperative
that we have convenient access to dodecahedryl anions and free
radicals.  Knowledge of the energetic costs of preparing these
intermediates would be invaluable in their deployment.  Similarly,
the strain energies of several unsaturated compounds, the
consequences of tethering dodecahedryl ring systems, and the
expectedly rich chemistry of homododecahedrane.  derived compounds
are to be intensely explored.  The heat of formation of dodeca.
hedrane is a value of importance to the scientific community as a
whole.  Finally, we intend to dedicate effort to the elaboration
of larger spherical molecules such as pentakai- and
hexakaidecahedrane and to obtaining their monoamino derivatives for
antiviral bioassay.

## Key facts

- **NIH application ID:** 3124965
- **Project number:** 5R01AI011490-18
- **Recipient organization:** OHIO STATE UNIVERSITY
- **SAM.gov UEI:** DLWBSLWAJWR1
- **Principal Investigator:** LEO A PAQUETTE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $174,304
- **Award type:** 5
- **Project period:** 1978-05-01 → 1993-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3124965

## Citation

> US National Institutes of Health, RePORTER application 3124965, POLYCONDENSED ALICYCLICS AND THEIR ANTIVIRAL ROLE (5R01AI011490-18). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3124965. Licensed CC0.

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