# STUDIES ON ANTIBODY AFFINITY AT THE CELLULAR LEVEL

> **NIH NIH R01** · WEILL MEDICAL COLL OF CORNELL UNIV · 1987 · $152,293

## Abstract

Studies on the maturation of the B-cell population are proposed.  The role of
the thymus in regulating the maturation of the function of the B-cell population
will be studied.  Three aspects of B-cell function will be evaluated:  (1)
ontogeny of the capacity to produce a heterogeneous response to a T-independent
antigen; (2) ontogeny of the capacity to resynthesize surface immunoglobulin
after capping with anti-immunoglobulin; (3) the ontogeny of the resistance to
tolerance induction which is typical of mature B cells.  The studies will be
carried out using cell transfer methods to evaluate the function of B cells from
donors of various ages transferred into lethally irradiated adult recipients.
The influence of thymus cells on B-cell maturation will be evaluated.

## Key facts

- **NIH application ID:** 3125002
- **Project number:** 5R01AI011694-12
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **SAM.gov UEI:** YNT8TCJH8FQ8
- **Principal Investigator:** GREGORY W SISKIND
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $152,293
- **Award type:** 5
- **Project period:** 1977-06-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125002

## Citation

> US National Institutes of Health, RePORTER application 3125002, STUDIES ON ANTIBODY AFFINITY AT THE CELLULAR LEVEL (5R01AI011694-12). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125002. Licensed CC0.

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