# BIOCHEMICAL CYTOLOGY OF TRICHOMONAS VAGINALIS

> **NIH NIH R01** · ROCKEFELLER UNIVERSITY · 1988 · $185,302

## Abstract

The project represents a continued study of the biochemical cytology of
Trichomonas vaginalis, a sexually transmitted common parasite that causes
vaginitis and urethritis in humans.  This organism is characterized by
fermentative metabolism with hydrogen as a major endproduct and thee
presence of hydrogenosomes, characteristic organelles of pyruvate
metabolism.  These organelles replace mitochondria and can be regarded as
their anaerobic equivalents.  Their enzyme composition resembles in many
respects that of primitive anaerobic bacteria.  The project aims at further
exploration of the hydrogenosomes of T. vaginalis with the aim of obtaining
information on the biological nature and phyletic relationships of this
organelle.  The primary structure of several hydrogenosomal proteins will
be determined by molecular cloning starting from mRNA and compared with
that of homologous molecules from prokaryotic and eukaryotic microorganisms
and organelles for which amino acid sequence data are available.  The
existence of extension(s) and sequences within the mature protein that
could play a role in intracellular targeting of these proteins will also be
explored.  To establish the relationships with other membrane bounded
organelles the biosynthesis of hydrogenosomal proteins and the
incorporation of newly synthesized polypeptides into isolated organelles
will be studied.  Regulation of these processes will be studied with the
use of organisms with deficient hydrogenosomes.

## Key facts

- **NIH application ID:** 3125060
- **Project number:** 5R01AI011942-14
- **Recipient organization:** ROCKEFELLER UNIVERSITY
- **SAM.gov UEI:** LHGDNJMZ64Y1
- **Principal Investigator:** MIKLOS MULLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $185,302
- **Award type:** 5
- **Project period:** 1978-07-01 → 1991-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125060

## Citation

> US National Institutes of Health, RePORTER application 3125060, BIOCHEMICAL CYTOLOGY OF TRICHOMONAS VAGINALIS (5R01AI011942-14). Retrieved via MORVS 2026-10-24 from https://api.morvs.ai/grant/nih/3125060. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*