# MOLECULAR PATHOGENESIS OF ADENO DISEASES-ANIMAL MODELS

> **NIH NIH R01** · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1992 · $251,974

## Abstract

Despite extensive structural, replicative, and genetic knowledge of
adenoviruses and the different diseases produced by the 42 distinct types,
little is known about the molecular mechanisms responsible for the
pathogenesis of any of these diseases.  The major goal of the proposed
research is to use the cotton rat and mouse models previously described to
investigate the molecular mechanism of the pathogenesis of adenovirus
pneumonia.  These studies will be directed toward determining:  1) the gene
functions required to produce the pneumonia; 2) which early gene functions
are expressed and in which cells other than the epithelial cells of the
bronchi and bronchiols; 3) the specific cell types that compose the
inflammatory response; 4) the specific role of the cytokines TNFalpha, IL-
1, and IL-6; 5) the role of cellular immunity and which viral antigens are
required in the second phase of the pulmonary response, and 6) which
gene(s) are critical to allow Ad7 to produce a much more severe pneumonia
than Ad5, Ad11 to cause hemorrhagic cystitis, and Ad40 to induce severe
infantile gastroenteritis.  Studies will be done to determine whether the
cytokine responses observed play a role in the pathogenesis of influenza A,
poliomyelitis, and herpes simplex encephalitis.

## Key facts

- **NIH application ID:** 3125089
- **Project number:** 2R01AI012052-19
- **Recipient organization:** COLUMBIA UNIV NEW YORK MORNINGSIDE
- **SAM.gov UEI:** F4N1QNPB95M4
- **Principal Investigator:** HAROLD S GINSBERG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $251,974
- **Award type:** 2
- **Project period:** 1977-09-01 → 1996-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125089

## Citation

> US National Institutes of Health, RePORTER application 3125089, MOLECULAR PATHOGENESIS OF ADENO DISEASES-ANIMAL MODELS (2R01AI012052-19). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125089. Licensed CC0.

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