# BIOCHEMICAL CHANGES IN ADENO-TRANSFORMED/INFECTED CELLS

> **NIH NIH R01** · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1989 · $263,718

## Abstract

The broad goals of the research proposed in this application are
directed toward gaining knowledge of the molecular reactions
essential in several of adenovirus' pathogenic processes:  acute
pneumonia, latent or persistent infections, and cellular
transformation.  To approach these goals the following specific
aims will be pursued:  1) Identification of the gene functions
essential for pathogenesis of pneumonia in an animal model that
pathologically is similar to that in humans, i.e., infection of the
cotton rat; 2) Study of the mechanisms of the establishment of
persistent infections of human T-4 lymphocytes; and 3)
Investigate the mechanism by which the early regions 1a and 1b
induce and maintain cellular transformation.  One other specific
aim will also be followed:  Complete the characterization of
newly isolated conditionally lethal, temperature-sensitive mutants
of the E2a DNA-binding protein to attain better understanding of
the several functions of this protein.

## Key facts

- **NIH application ID:** 3125093
- **Project number:** 5R01AI012052-16
- **Recipient organization:** COLUMBIA UNIV NEW YORK MORNINGSIDE
- **SAM.gov UEI:** F4N1QNPB95M4
- **Principal Investigator:** HAROLD S GINSBERG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $263,718
- **Award type:** 5
- **Project period:** 1977-09-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125093

## Citation

> US National Institutes of Health, RePORTER application 3125093, BIOCHEMICAL CHANGES IN ADENO-TRANSFORMED/INFECTED CELLS (5R01AI012052-16). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125093. Licensed CC0.

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