# MYCOPLASMA/CELL INTERACTIONS

> **NIH NIH R01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 1989 · $157,889

## Abstract

The overall aim of this study is to determine the requirements necessary
for activation of T-lymphocytes in response to mitogens and antigens.
These studies will be undertaken using a unique haplotype-dependent, T-cell
mitogen derived from Mycoplasma arthritidis.  More specifically, our
research is directed toward the following aims:

1) Purification and characterization of the T-cell mitogen derived from M.
arthritidis.

2) Accessory cell requirements for presentation of mitogen and antigen to
T-lymphocytes and role of soluble mediators.

3) Differential accessory cell requirements for activation of T-cells,
T-hybridomas and T-cell clones.

4) Mechanisms of T-cell recognition of processed mitogen and antigens.

5) Mechanisms and gene control of non-MHC factors in mice and rats which
suppress responsiveness to mitogens and antigens.

## Key facts

- **NIH application ID:** 3125112
- **Project number:** 5R01AI012103-13
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **SAM.gov UEI:** LL8GLEVH6MG3
- **Principal Investigator:** BARRY C COLE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $157,889
- **Award type:** 5
- **Project period:** 1978-03-01 → 1990-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125112

## Citation

> US National Institutes of Health, RePORTER application 3125112, MYCOPLASMA/CELL INTERACTIONS (5R01AI012103-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125112. Licensed CC0.

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