# CELLULAR ACTIVATION

> **NIH NIH R01** · HAHNEMANN UNIVERSITY · 1987 · $199,497

## Abstract

The proposed work is designed to study the interactions between the products of
antigen-stimulated immunocompetent cells and other cell types in various forms
of cell-mediated immunity.  Our current work will focus on murine models.  We
will investigate lymphokine production in abnormal strains such as the NZB/W
mouse.  In this animal there is diminished reactivity to DNA and other antigens
with respect to delayed hypersensitivity.  This hyporeactivity may be corrected
with prostaglandins in vivo.  We will determine whether the defect is at the
level of MIF and/or chemotactic factor production.  Additional experiments will
focus on the detection of chemotactic events in vivo.  The model to be used here
involves the installation of antigen or performed mediator into the peritoneal
cavity and determining the kinetics of the various types of inflammatory cells.
In those studies involving production of mediators, we will pay special
attention to the role of ancillary helping cells such as the macrophage.  We
will determine the relative capacity of such phagocytic cells from various
sources to serve such a role and attempt to determine the mechanism by which
such interaction occurs.

## Key facts

- **NIH application ID:** 3125204
- **Project number:** 7R01AI012477-13
- **Recipient organization:** HAHNEMANN UNIVERSITY
- **Principal Investigator:** STANLEY COHEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $199,497
- **Award type:** 7
- **Project period:** 1987-06-01 → 1988-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125204

## Citation

> US National Institutes of Health, RePORTER application 3125204, CELLULAR ACTIVATION (7R01AI012477-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125204. Licensed CC0.

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