# MECHANISMS OF NONSTERILIZING IMMUNITY IN MALARIA

> **NIH NIH R01** · HAHNEMANN UNIVERSITY · 1989 · $255,544

## Abstract

The overall goal of the proposed research is to investigate the
biology of T lymphocytes activated by murine plasmodia with the aim
of understanding how these cells participate in protective immune
response during malaria.  In particular, attention will be focused
on antibody-independent cell mediated protective immune responses
leading to parasite death or growth inhibition.  Antigen-specific
protective T-cell clones including CTR2.1 and others to be
developed against P. chabaudi adami as well as against P. vinckei
petteri and B. microti utilizing in vitro culture techniques will
be tested for their protective activity in vivo against homologous
and heterologous parasites by means of adoptive transfer into
histocompatible nude mice.  Protective and nonprotective T-cell
clones will be characterized according to surface antigens,
lymphokine production, antigenic specificity, and trafficking in
an effort to identify characteristics distinctive of protective
cloned T cells.  In addition, experiments will be undertaken to
characterize the biological function of protective T-cell clones
both in vitro and in vivo in order to determine whether they kill
parasites through the release of specific mediators or activate
additional cell types in a common pathway of resistance.  Efforts
will also be made to determine whether the function of malaria-
protective cloned T cells can be modulated by T cells displaying
antigen-specific suppressive activity.

## Key facts

- **NIH application ID:** 3125259
- **Project number:** 5R01AI012710-14
- **Recipient organization:** HAHNEMANN UNIVERSITY
- **Principal Investigator:** WILLIAM Paul WEIDANZ
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $255,544
- **Award type:** 5
- **Project period:** 1975-06-01 → 1990-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125259

## Citation

> US National Institutes of Health, RePORTER application 3125259, MECHANISMS OF NONSTERILIZING IMMUNITY IN MALARIA (5R01AI012710-14). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125259. Licensed CC0.

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