# IMMUNOBIOLOGY OF LY+ T-CELL SUBCLASSES

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1988 · $279,634

## Abstract

After activation, T-cells express a set of genes which encode the
inducer cell's functional program.  Other T-cell genes define the
essentials of the cell's specialized physiology in terms of normal
and neoplastic growth.  To identify these genes, we have screened
a panel of cDNAs which are selectively expressed by resting and
activated T-cell clones.  The transcription of one such gene, TCR-
7, decreases after activation.  The deduced sequence of the TCR-
7 predicts a 41,330 dalton intracellular protein.  The TCR-7 gene
encoding this protein maps by RFLP near the HBB locus on
chromosome 7.  Further analysis of TCR-7 expression suggests the
possibility that it may negatively regulate IL-2 receptor
expression in L3T4+ inducer cells but not Ly2+ T-cells.

We have also developed a panel of T-cell clones that co-recognize
hapten and MHC products.  Although there is good evidence that
genes encoding alpha and beta heterodimers account in some
fashion for co-recognition by T-cells, the structural basis for
recognition of antigen-MHC complexes is not clear.  The
protocols and methodology detailed in Specific Aim II are
intended to directly establish the structural contribution of the
alpha and beta chains to T-cell recognition of antigen, using
clones that are specific for well-defined haptens.

## Key facts

- **NIH application ID:** 3125511
- **Project number:** 5R01AI013600-12
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** HARVEY CANTOR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $279,634
- **Award type:** 5
- **Project period:** 1976-06-01 → 1992-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125511

## Citation

> US National Institutes of Health, RePORTER application 3125511, IMMUNOBIOLOGY OF LY+ T-CELL SUBCLASSES (5R01AI013600-12). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125511. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*