# INFLAMMATORY RESPONSES IN ALLERGIC REACTIONS AND ASTHMA

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 1988 · $255,362

## Abstract

The overall objective of this project is to extend previous skin
chamber and histologic studies in this lab to farther delineate
underlying mechanisms in human allergic skin reactions.  Specific
objectives are to:  1) compare patterns of local mediator release
induced by continuous vs interrupted antigen challenge and relate
patterns and degrees of such responses to late phase cutaneous
allergic reactions (LACR); 2) determine the cellular source of the
continued low-level histamine release and the mechanisms underlying
an antigen-specific desensitization developing during continuous
antigen challenge; 3) determine the cell source of LTB4 and PAF
secreted in such reactions; 4) determine whether neutrophil and
eosinophil products released in such reaction sites have pathogenic
effects on dermal components like elastin, collagen, vascular
endothelium; 5) determine the intracellular pathways of neutrophil
activation induced by factors released in allergic reaction sites:
6) determine whether factors released on allergic reaction sites;
a) affect further mediator release in vivo and in vitro; b) affect
function of lymphocytes and monocytes; 7) determine in biopsy
studies:  a) whether neutrophils become activated as they enter the
dermis during allergic reactions; b) whether basophils could be a
source of the local continued histamine release observed.  These
objectives will be approached by applying immunoassays, bioassays,
enzyme assays, chromatography, and immunohistochemical techniques
to studies of skin chamber and biopsy specimens.  The hypotheses
to be tested are that allergic skin responses are complex, often
prolonged, involving several interacting cell types, with release
of cell factors which are pathogenic for surrounding tissues.
Findings should help our understanding of LACR and allergic
inflammation.

## Key facts

- **NIH application ID:** 3125687
- **Project number:** 2R01AI014332-12
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **SAM.gov UEI:** GM1XX56LEP58
- **Principal Investigator:** BURTON ZWEIMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $255,362
- **Award type:** 2
- **Project period:** 1977-09-01 → 1993-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125687

## Citation

> US National Institutes of Health, RePORTER application 3125687, INFLAMMATORY RESPONSES IN ALLERGIC REACTIONS AND ASTHMA (2R01AI014332-12). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125687. Licensed CC0.

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