# INFLAMMATORY RESPONSES IN ALLERGIC REACTIONS AND ASTHMA

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 1987 · $255,997

## Abstract

The overall objective of this project is to further characterize the
underlying mechanisms and significance of inflammatory cell responses in
the sites of human allergic reactions.  The overall approach will utilize
techniques adapted by us that permit:  1) sequential measurements of
mediator release and inflammatory cell responses in the skin reactions to
pollen antigens; 2) sequential measurement of allergic serum chemotactic
factors and other mediators after antigen inhalation challenge.  Specific
aims include determination:  1) Whether a single antigen challenge in the
skin of sensitive subjects leads to a single burst or continued mediator
release and how this relates to sequential inflammatory cell responses.  2)
Whether qualitatively different mediator release patterns occur in
immediate and delayed responses to intradermal or inhaled antigen and how
this relates to clinical manifestations of the subjects.  3) The effects of
the local allergic environment on subsequent mediator release and
inflammatory cell function.  4) The source and biologic effects of
neutrophil chemotactic activity we found to be increased during
antigen-induced bronchospasm.  5) The effects of immunotherapy on such
responses.  Findings in this project may provide a basis for more effective
treatment in human allergic diseases.

## Key facts

- **NIH application ID:** 3125692
- **Project number:** 5R01AI014332-11
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **SAM.gov UEI:** GM1XX56LEP58
- **Principal Investigator:** BURTON ZWEIMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $255,997
- **Award type:** 5
- **Project period:** 1977-09-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125692

## Citation

> US National Institutes of Health, RePORTER application 3125692, INFLAMMATORY RESPONSES IN ALLERGIC REACTIONS AND ASTHMA (5R01AI014332-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125692. Licensed CC0.

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