# MICROHETEROGENEITY OF IA MOLECULES AND IR GENE FUNCTION

> **NIH NIH R01** · YALE UNIVERSITY · 1987 · $205,349

## Abstract

Previous studies supported by this grant have provided a clear picture of
the expression of Ia glycoprotein antigens on the lymphocyte surface.  In
addition, we have shown that Ia antigens are the molecular products of
immune response (Ir) genes, and that quantitative as well as qualitative
(allelic) differences in Ia expression influence immune response
potential.  The goals of the current proposal are to 1) determine the
extent, nature, and functional relevance of quantitative and qualitative
microheterogeneity in the expression of Ia molecules on the cell surface,
which has only been peripherally explored, and 2) determine whether
suppression universally accounts for nonresponsiveness in Ir nonresponder
mice, and explore possible mechanisms of this nonresponsiveness (e.g. self
tolerance).  To achieve these goals, we will utilize conventional Ia
antisera and monoclonal Ia antibodies, two dimensional gel electrophoresis,
and T cells and cloned autoreactive T cell lines to probe the genetics,
expression, and biology of Ir products.  In addition, we will apply two
novel systems which we have developed to the analysis of the role of immune
suppression in self tolerance and Ir gene function (contrasuppression and
stimulation in I-J disparate strains).  The long term objective of this
research is to determine the contribution of quantitative and qualitative
microheterogeneity in Ia expression to immune response capacity, and to
determine the precise mechanism(s) of Ir gene control.

## Key facts

- **NIH application ID:** 3125702
- **Project number:** 5R01AI014349-11
- **Recipient organization:** YALE UNIVERSITY
- **SAM.gov UEI:** FL6GV84CKN57
- **Principal Investigator:** DONAL B. MURPHY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $205,349
- **Award type:** 5
- **Project period:** 1977-09-01 → 1988-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125702

## Citation

> US National Institutes of Health, RePORTER application 3125702, MICROHETEROGENEITY OF IA MOLECULES AND IR GENE FUNCTION (5R01AI014349-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125702. Licensed CC0.

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