# GENETICS & BIOCHEMISTRY OF PLASMID TRANSFER

> **NIH NIH R01** · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · 1989 · $185,048

## Abstract

The dissemnation of plasmid DNA elements among bacteria
provides one of the most important mechanisms through which
bacteria gain new pathogenic traits and other genetic
characteristics that complicate clinical therapy.  Using the F
plasmid conjugation system of Escherichia coli as a model, we are
studying the genes and gene products required for the
transmission of F DNA from one cell to another.  During our
genetic and protein product analysis of genes in the F transfer
region we have discovered a number of previously unrecognized
coding sequences, and identified activities that are involved in
making F-pilin.  We now plan to complete a DNA sequence
analysis of the F DNA segment which includes transfer genes traC
through trbB and to characterize the transfer related function of
the new loci in this region.  We also propose experiments designed
to characterize the biochemical steps of F-pilin synthesis and the
role of traQ and other tra functions in this process.

## Key facts

- **NIH application ID:** 3125746
- **Project number:** 5R01AI014426-13
- **Recipient organization:** TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- **SAM.gov UEI:** HFT7XTHB6563
- **Principal Investigator:** KARIN A IPPEN-IHLER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1989
- **Award amount:** $185,048
- **Award type:** 5
- **Project period:** 1978-09-01 → 1993-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125746

## Citation

> US National Institutes of Health, RePORTER application 3125746, GENETICS & BIOCHEMISTRY OF PLASMID TRANSFER (5R01AI014426-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125746. Licensed CC0.

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