# DEVELOPMENT OF A VIRUS MEMBRANE

> **NIH NIH R01** · UNIVERSITY OF TEXAS AT AUSTIN · 1992 · $166,217

## Abstract

It is the goal of this research to elucidate the molecular events
leading to the formation of an infectious enveloped virus (the
alphavirus Sindbis) from its component parts.  Specifically, this
research program will have four primary goals:  1) The elucidation
of the types of virus protein/protein interactions and processing
events essential for transport and assembly of virus components
into infectious virions; 2) The identification of host functions
involved in the transport and development of functional virus
membrane proteins; 3) Determination of the 3-dimensional structure
of Sindbis virus by X-ray crystallography; 4) The elucidation of
the organization of Sindbis virus RNA and protein interactions
within the nucleocapsid.

In pursuing these objectives, information will be gathered which
is important to understanding the mechanisms employed by cells in
the production, processing and transport of cell plasma membrane
proteins, as well as the molecular organization of the RNA, lipid,
and protein components of an important group of human and animal
pathogens.

## Key facts

- **NIH application ID:** 3125842
- **Project number:** 5R01AI014710-12
- **Recipient organization:** UNIVERSITY OF TEXAS AT AUSTIN
- **SAM.gov UEI:** V6AFQPN18437
- **Principal Investigator:** Dennis T Brown
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $166,217
- **Award type:** 5
- **Project period:** 1978-09-01 → 1994-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125842

## Citation

> US National Institutes of Health, RePORTER application 3125842, DEVELOPMENT OF A VIRUS MEMBRANE (5R01AI014710-12). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125842. Licensed CC0.

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