# REGULATION OF B CELL CLONAL DIVERSITY

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1990 · $245,814

## Abstract

In both man and mouse it has been shown that the early repertoire of T
and B cells differs considerably from that of the adult with respect to V
gene family expression, the specificity of receptors and the functions
and phenotypes of both lineages. In this proposal we will continue to
analyze the developmental regulation of the B cell repertoire in mice. We
propose that the Ly1+ B cell subset is a separate lineage o beta cells
derived from the omentum and that these cells are primarily responsible
for the establishment of the early beta cell repertoire. We will also
determine whether the omentum is involved in the extrathymic generation
of subsets of T cells. We will investigate at a molecular and cellular
level the specificities and lymphocyte activating properties of
antibodies produced by these cells as well as their potential to
synthesize interleukins which may be involved in the regulation of growth
and differentiation of other lymphoid cells.

These studies will focus on the origin of these subpopulations of
lymphocytes, their role in the ontogeny of the immune response and
maintenance of the Beta and T cell repertoires. These experiments may
reveal in the long-term why deregulation of Lyl and CD5+ Bell cells are
involved in certain autoimmune and Beta cell neoplastic diseases in mouse
and similar diseases in man.

## Key facts

- **NIH application ID:** 3125882
- **Project number:** 5R01AI014782-13
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **SAM.gov UEI:** YND4PLMC9AN7
- **Principal Investigator:** John Franklin Kearney
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $245,814
- **Award type:** 5
- **Project period:** 1978-09-01 → 1994-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125882

## Citation

> US National Institutes of Health, RePORTER application 3125882, REGULATION OF B CELL CLONAL DIVERSITY (5R01AI014782-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125882. Licensed CC0.

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