# REGULATION OF B CELL CLONAL DIVERSITY

> **NIH NIH R01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1992 · $284,071

## Abstract

In both man and mouse it has been shown that the early repertoire of T and
B cells differs considerably from that of the adult with respect to V gene
family expression, the specificity of receptors and the functions and
phenotypes of both lineages.  In this proposal we will continue to analyze
the developmental regulation of the B cell repertoire in mice.  We propose
that the Ly1+ B cell subset is a separate lineage of beta cells derived
from the omentum and that these cells are primarily responsible for the
establishment of the early beta cell repertoire.  We will also determine
whether the omentum is involved in the extrathymic generation of subsets of
T cells.  We will investigate at a molecular and cellular level the
specificities and lymphocyte activating properties of antibodies produced
by these cells as well as their potential to synthesize interleukins which
may be involved in the regulation of growth and differentiation of other
lymphoid cells.

These studies will focus on the origin of these subpopulations of
lymphocytes, their role in the ontogeny of the immune response and
maintenance of the Beta and T cell repertoires.  These experiments may
reveal in the long-term why deregulation of Lyl and CD5+ B cells are
involved in certain autoimmune and Beta cell neoplastic diseases in mouse
and similar diseases in man.

## Key facts

- **NIH application ID:** 3125884
- **Project number:** 5R01AI014782-15
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **SAM.gov UEI:** YND4PLMC9AN7
- **Principal Investigator:** John Franklin Kearney
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $284,071
- **Award type:** 5
- **Project period:** 1978-09-01 → 1994-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125884

## Citation

> US National Institutes of Health, RePORTER application 3125884, REGULATION OF B CELL CLONAL DIVERSITY (5R01AI014782-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125884. Licensed CC0.

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