# HUMAN IMMUNITY TO THE GROUP B STREPTOCOCCI

> **NIH NIH R01** · LOS ANGELES COUNTY HARBOR-UCLA MED CTR · 1987 · $145,346

## Abstract

This application is to continue studies of the human immune response to the
group B streptococci (GBS), a major cause of infection in newborn infants,
in order to determine ways in which immunity may influence infection with
and carriage of GBS.  An enzyme-linked-immunosorbent assay and other assays
will be used to quantitate antibody of the various immunoglobulin
subclasses to purified type- and group-specific carbohydrates of GBS.  Sera
from pregnant patients, their infants, healthy adults, infected infants,
adult recipients of group B streptococcal vaccines, and healthy infants and
children of different ages will be studied.  The biological activity of
whole human serum and purified immunoglobulin fractions will be compared in
newborn rats infected with GBS.  Antibody in breast milk and other
secretions will be studied to define the secretory immune response to GBS
carriage and to determine any relationships between secretory immunity and
carriage of GBS.

## Key facts

- **NIH application ID:** 3125901
- **Project number:** 5R01AI014827-09
- **Recipient organization:** LOS ANGELES COUNTY HARBOR-UCLA MED CTR
- **Principal Investigator:** Bascom F. Anthony
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $145,346
- **Award type:** 5
- **Project period:** 1979-01-01 → 1988-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125901

## Citation

> US National Institutes of Health, RePORTER application 3125901, HUMAN IMMUNITY TO THE GROUP B STREPTOCOCCI (5R01AI014827-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125901. Licensed CC0.

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