# B LACTAM AND AMINO ACID DERIVED ANTIBIOTIC BIOSYNTHESIS

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1988 · $172,973

## Abstract

A research program is described that will continue biosynthetic studies
with the nocardicins, the prototype monocyclic Beta-lactam antibiotic, and
clavulanic acid, a potent inhibitor of bacterial beta-lactamases.  These
studies are to be extended to the remarkable antipodal clavams and to the
medicinally important carbapenems using carbapenem-3-carboxylic acid as the
experimental system.  In collaboration with workers at Eli Lilly,
biosynthetic investigation of the glycopeptide antibiotics represented by
vancomycin will be initiated.  The potential role of beta-oxidized amino
acids will be examined in clavulanic acid, carbapenems (and gamma-oxidized
in clavams) and further developed in new studies of the C-nucleoside
antibiotics showdomycin and pyrazofurin.

## Key facts

- **NIH application ID:** 3125941
- **Project number:** 5R01AI014937-10
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** CRAIG ARTHUR TOWNSEND
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $172,973
- **Award type:** 5
- **Project period:** 1978-09-01 → 1989-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125941

## Citation

> US National Institutes of Health, RePORTER application 3125941, B LACTAM AND AMINO ACID DERIVED ANTIBIOTIC BIOSYNTHESIS (5R01AI014937-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125941. Licensed CC0.

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