# IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONS

> **NIH NIH R01** · UNIVERSITY OF TENNESSEE KNOXVILLE · 1993 · $237,192

## Abstract

The goal of this research is to provide a further understanding of
interactions between the effectors and regulators of the immune
response to herpes simplex virus (HSV) so that effective vaccines
could be designed to control herpetic disease.  The major emphasis
of this phase of the research will be to explore the role of major
histocompatibility complex restricted (MHC) class I and class II
restricted cytotoxic T lymphocytes.  Experiments are designed 1)
to identify individual viral subcomponents that act as targets for
class I and II restricted CTL in mice of various strains; 2) to
define the optimal means of inducing CTL in vivo and in vitro and
to find explanations for the apparent failure of some major
glycoproteins to act as CTL targets and inducers; 3) to identify
CTL recognizable epitopes on target proteins; 4) to further resolve
the role of class I and class II restricted CTL of different
specificities in controlling HSV pathogenesis; and, 5) to evaluate
the role of suppressor mechanisms in regulating effector aspect of
T cell mediated that serve to curtail infections.

## Key facts

- **NIH application ID:** 3125964
- **Project number:** 5R01AI014981-16
- **Recipient organization:** UNIVERSITY OF TENNESSEE KNOXVILLE
- **SAM.gov UEI:** FN2YCS2YAUW3
- **Principal Investigator:** Barry T. Rouse
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1993
- **Award amount:** $237,192
- **Award type:** 5
- **Project period:** 1978-05-01 → 1994-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3125964

## Citation

> US National Institutes of Health, RePORTER application 3125964, IMMUNITY MECHANISMS IN HERPESVIRUS INFECTIONS (5R01AI014981-16). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3125964. Licensed CC0.

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