# CELL SURFACE RECEPTORS ON CYTOTOXIC T CELLS

> **NIH NIH R01** · BETH ISRAEL DEACONESS MEDICAL CENTER · 1992 · $248,852

## Abstract

DESCRIPTION:  (Adapted from the applicant's abstract) The hypothesis to be
tested in this project is that protein/protein interactions between the
cytoplasmic domains of CD3 proteins and signalling molecules will initiate
different pathways.  Functional networking with other T cell activation
molecules will be analyzed at each step.  Specifically the following aims
will be attempted.  Generation of lymphocytes which are blocked in signal
transduction through the TCR/CD3 Complex; determination of the role of
tyrosine- and serine/threonine-phospho-kinases associated with the TCR/CD3
Complex; identification and isolation of guanine or adenosine
nucleotide-binding proteins involved in T cell functions; isolation of
proteins which have a propensity to associate with the intracellular
domains of the CD3-gamma, delta, epsilon and zeta proteins.

## Key facts

- **NIH application ID:** 3126003
- **Project number:** 5R01AI015066-15
- **Recipient organization:** BETH ISRAEL DEACONESS MEDICAL CENTER
- **SAM.gov UEI:** C1CPANL3EWK4
- **Principal Investigator:** CORNELIS P TERHORST
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1992
- **Award amount:** $248,852
- **Award type:** 5
- **Project period:** 1978-08-01 → 1996-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126003

## Citation

> US National Institutes of Health, RePORTER application 3126003, CELL SURFACE RECEPTORS ON CYTOTOXIC T CELLS (5R01AI015066-15). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126003. Licensed CC0.

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