# POLIOVIRUS  MOLECULAR BIOLOGY AND SURFACE STRUCTURE

> **NIH NIH R01** · STATE UNIVERSITY NEW YORK STONY BROOK · 1987 · $251,764

## Abstract

We propose to continue and greatly extend our studies on the molecular
biology of picornaviruses, particularly on poliovirus.  We shall study
aspects of viral protein synthesis (initiation and processing of
polypeptides) and the intriguing problem of viral RNA replication.  We will
use recombinant DNA technology to define gene function (in vitro
recombination, site specific mutagenesis) and we plan to characterize the
surface properties of the virion (neutralizing epitopes, virus-cell
attachment sites).  Our studies may lead to the development of new vaccines
and drugs directed against picornavirus infection.

## Key facts

- **NIH application ID:** 3126019
- **Project number:** 5R01AI015122-14
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **SAM.gov UEI:** M746VC6XMNH9
- **Principal Investigator:** Eckard Wimmer
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $251,764
- **Award type:** 5
- **Project period:** 1978-04-01 → 1988-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126019

## Citation

> US National Institutes of Health, RePORTER application 3126019, POLIOVIRUS  MOLECULAR BIOLOGY AND SURFACE STRUCTURE (5R01AI015122-14). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126019. Licensed CC0.

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