# THE MOLECULAR PATHOLOGY OF LPS-INDUCED INJURY

> **NIH NIH R01** · SCRIPPS CLINIC AND RESEARCH FOUNDATION · 1988 · $333,550

## Abstract

It is now appreciated that bacterial lipopolysaccharides (LPS) are
responsible for initiating the pathophysiologic changes occurring in
patients with gram-negative septicemia.  The high mortality rate in this
group of patients contributes to one of leading causes of death in the
United States.  The long range goal of this renewal proposal is to define
the biochemical mechanisms of LPS interactions with key plasma proteins and
tissue-fixed cells and to relate the interactions to the development of
injury.  The proposed studies will focus specifically on three areas:  (i)
studies of the mechanism of interaction of LPS with normal and acute phase
serum paying particular attention to the regulation of LPS-high density
lipoprotein (HDL) binding and to structure/function studies of the LPS-HDL
complex, (ii) investigation of how cells recognize the presence of LPS by
specifically characterizing the cell membrane components which interact
with LPS and lead to cell activation, and (iii) characterization of the
enzymatic mechanisms in the macrophage which lead to arachidonic acid
release with specific emphasis on the isolation and characterization of
phospholipases which catalyze arachidonic acid release from phospholipid.
In addition to the relevance of the proposed studies to understanding the
mechanism of action of LPS, these studies will provide more general
information about the role of acute phase reactants in regulating the host
response to inflammatory stimuli, about the molecular basis of the early
steps of B-cell activation and about the properties of the phospholipases
which may control the production of potent mediators (prostaglandins and
leukotrienes) of injury in a wide variety of pathologic conditions.

## Key facts

- **NIH application ID:** 3126032
- **Project number:** 5R01AI015136-10
- **Recipient organization:** SCRIPPS CLINIC AND RESEARCH FOUNDATION
- **Principal Investigator:** Richard J Ulevitch
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $333,550
- **Award type:** 5
- **Project period:** 1978-08-01 → 1990-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126032

## Citation

> US National Institutes of Health, RePORTER application 3126032, THE MOLECULAR PATHOLOGY OF LPS-INDUCED INJURY (5R01AI015136-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126032. Licensed CC0.

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