# CONTROL OF JUVENILE HORMONE SYNTHESIS

> **NIH NIH R01** · UNIVERSITY OF IOWA · 1988 · $90,479

## Abstract

The long term objective is to understand the regulation of juvenile
hormone (JH) synthesis by the corpora allata (CA).

The system studied is the female reproductive cycle of the
viviparous cockroach, Diploptera punctata, in which egg
development is precisely controlled by cyclic changes in
production of JH by the CA.  This serves as a model system for
understanding the regulation of the CA, an important step in
developing methods to limit insect reproduction.

The specific aims are to demonstrate how the brain and the ovary
act on the CA to alternately stimulate and inhibit the production
of JH.  The inhibitory and stimulatory factors from these organs
will be isolated and their source and mode of action
characterized.  The cellular and subcellular organization and
biochemistry of the CA will be correlated with changes in JH
production by the glands during the reproductive cycle.

JH synthesis will be measured by a direct short term in vitro
radiochemical assay following treatment with extracts of nervous
tissue and ovaries.  Extracts will be purified with HPLC.  The
source of the active factors will be demonstrated by cytochemical
and immunocytochemical methods.  Changes in cellular and
subcellular organization will be sought in electron microscopical
analyses including autoradiography and stereological
measurements.

## Key facts

- **NIH application ID:** 3126062
- **Project number:** 5R01AI015230-09
- **Recipient organization:** UNIVERSITY OF IOWA
- **SAM.gov UEI:** Z1H9VJS8NG16
- **Principal Investigator:** BARBARA A STAY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $90,479
- **Award type:** 5
- **Project period:** 1979-05-01 → 1990-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126062

## Citation

> US National Institutes of Health, RePORTER application 3126062, CONTROL OF JUVENILE HORMONE SYNTHESIS (5R01AI015230-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126062. Licensed CC0.

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