# MACROPHAGE ACTIVATION IN EXPERIMENTAL MALARIA

> **NIH NIH R01** · NEW YORK UNIVERSITY · 1990 · $185,660

## Abstract

Immune complexes are present in the sera of rodents, primates and humans
infected with malaria.  These immune complexes inhibit phagocytosis and
antibody dependent cell-mediated cytotoxicity.  Because malarial antigens
or peptides will eventually be used in a malarial vaccine, we propose to
determine whether several rodent, primate and human antigens and
antigen-antibody complexes are present in infected hosts.  These antigens
are of interest because they are putative protective antigens, some are
present on the erythrocyte surface, and some have repetitive epitopes.  The
antigens and immune complexes will be detected by radioimmunoassay using
specific monoclonal antibodies.  One antigen, Pc100, located on the surface
of Plasmodium chabaudi-infected erythrocytes will be purified and
incorporated into immune complexes made with monoclonal antibodies.  These
complexes will be injected into mice and their effect on the course of
malaria infection and on the mice will be determined.  Since Pc100 is a
model of an erythrocyte surface antigen which may be protective, it will be
characterized biochemically.  Further, the ability of monoclonal antibodies
against Pc100 and purified Pc100 to protect mice against lethal and
non-lethal P. chabaudi will be studied.

## Key facts

- **NIH application ID:** 3126087
- **Project number:** 2R01AI015235-12A2
- **Recipient organization:** NEW YORK UNIVERSITY
- **SAM.gov UEI:** NX9PXMKW5KW8
- **Principal Investigator:** HANNAH L SHEAR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $185,660
- **Award type:** 2
- **Project period:** 1978-07-01 → 1995-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126087

## Citation

> US National Institutes of Health, RePORTER application 3126087, MACROPHAGE ACTIVATION IN EXPERIMENTAL MALARIA (2R01AI015235-12A2). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126087. Licensed CC0.

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