# MACROPHAGE ACTIVATION IN EXPERIMENTAL MALARIA

> **NIH NIH R01** · NEW YORK UNIVERSITY · 1991 · $105,454

## Abstract

A better understanding of the mechanisms of protective immunity to malaria
are still needed.  Previous studies from this laboratory have determined
that there are important differences in the immune response to non-lethal
and lethal P. yoe1ii17x malaria and in the responses of malaria-
susceptible, compared with resistant mice.  We will now extend these
studies to another species of rodent malaria, P. chabaudi.  In order to
further understand the differences between lethal and non-lethal malaria,
we will analyze the activities of subpopulations of T helper cells and T
cytotoxic cells during the course of malaria infections by analyzing the
lymphokines produced during infection and the isotypes of Ig produced.  We
will also determine whether lymphocytes from mice with non-lethal
infections and resistant mice consistently produce higher levels of gamma-
IFN and whether their splenic macrophages secrete enhanced levels of
hydrogen peroxide, compared with mice with lethal infections.

Other studies from this laboratory have indicated that Pc96, an antigen on
the surface of Plasmodium chabaudi infected erythrocytes, is partially
protective in mice and may induce cell-mediated immunity.  In the studies
proposed, we will investigate the mechanism of protection induced by
immunization with this antigen using transfer of subpopulations of
lymphocytes and immune serum.  We will also use this antigen in
immunization studies with lymphokines as adjuvants.

## Key facts

- **NIH application ID:** 3126091
- **Project number:** 5R01AI015235-13
- **Recipient organization:** NEW YORK UNIVERSITY
- **SAM.gov UEI:** NX9PXMKW5KW8
- **Principal Investigator:** HANNAH L SHEAR
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1991
- **Award amount:** $105,454
- **Award type:** 5
- **Project period:** 1978-07-01 → 1991-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126091

## Citation

> US National Institutes of Health, RePORTER application 3126091, MACROPHAGE ACTIVATION IN EXPERIMENTAL MALARIA (5R01AI015235-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126091. Licensed CC0.

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