# TREATMENT OF INSECT STING ALLERGY IN CHILDREN

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 1988 · $227,493

## Abstract

Venom immunotherapy, already shown to be highly effective in prevention of
insect sting anaphylaxis in previously sensitized patients, remains
effective but brings little benefit to patients age 2-16 years whose
systemic reactions were limited to the skin.  Lack of benefit in this group
stems from a repeat reaction rate in unimmunized patients much lower than
expected from previous experience with insectallergic adults.  This
disparity will allow us to probe whether the low reaction rate is a
function of age, reaction type (cutaneous vs. respiratory, mucosal or
cardio-vascular) or another variable.  Additional goals include exploration
of whether in vivo or in vitro parameters of decline in anti-venom IgE
antibodies can be correlated with clinical evidence of attenuation of the
venom-allergic state.  We shall continue to document the natural history of
insect sting allergy without immunotherapeutic intervention in mildly
affected children.

## Key facts

- **NIH application ID:** 3126176
- **Project number:** 5R01AI015443-10
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **SAM.gov UEI:** FTMTDMBR29C7
- **Principal Investigator:** MARTIN D VALENTINE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $227,493
- **Award type:** 5
- **Project period:** 1978-12-01 → 1988-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126176

## Citation

> US National Institutes of Health, RePORTER application 3126176, TREATMENT OF INSECT STING ALLERGY IN CHILDREN (5R01AI015443-10). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126176. Licensed CC0.

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