# IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS

> **NIH NIH R01** · UNIVERSITY OF WISCONSIN-MADISON · 1990 · $101,289

## Abstract

The primary objectives of the proposed research is to continue to define
and characterize the molecular mechanisms underlying genetically determined
resistance and susceptibility in snails, Biomphalaria glabrata, to
infection by larvae of the human blood fluke, Schistosoma mansoni.
Genetically defined susceptible (PR albino) and resistant (10-R2, 13-16-R1,
243432) strains of B. glabrata will be employed in comparative
immunological and biochemical studies designed to provide an in-depth
analysis of the three interacting components involved in the immune
association between S. mansoni and its snail host:  the circulating
hemocyte, soluble hemolymph factors, and the tegumental surface of
schistosome larvae.  Specifically, monoclonal antibody probe methods, in
conjunction with in vitro cultivation, biochemical (e.g., HPLC), and
microinjection techniques, will be employed to (1) identify and
characterize molecularly distinct hemocyte populations and determine their
impact on parasite immune interactions, (2) analyze the soluble
constituents comprising the hemolymph of resistant snails and assess the
role of isolated serum factors in mediating schistosome recognition and/or
host hemocyte activation, (3) investigate the antigenic composition of the
larval schistosome surface with emphasis on the functional role of primary
sporocyst tegumental components in determining the degree of immune
compatibility exhibited by the different snail host strains, and (4)
establish an in vivo model for assessing the relative importance of
cellular and humoral defense elements in determining natural or induced
parasite resistance within the intact host.  The long-term goal of this
research is to establish a firm base from which the biochemical parameters
regulating immune interactions between various invertebrate vectors and
their human-infecting parasites can be precisely defined and eventually
applied to vector control methodologies.

## Key facts

- **NIH application ID:** 3126217
- **Project number:** 5R01AI015503-13
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **SAM.gov UEI:** LCLSJAGTNZQ7
- **Principal Investigator:** TIMOTHY P. YOSHINO
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1990
- **Award amount:** $101,289
- **Award type:** 5
- **Project period:** 1988-07-01 → 1992-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126217

## Citation

> US National Institutes of Health, RePORTER application 3126217, IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS (5R01AI015503-13). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126217. Licensed CC0.

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