# IMMUNITY TO SALMONELLA INFECTION

> **NIH NIH R01** · TEMPLE UNIV OF THE COMMONWEALTH · 1988 · $165,583

## Abstract

Investigations will continue into the basic mechanisms of host
defenses to Salmonella infection in mice, as a model of human
typhoid fever.  Mice in the C3H lineage will be immunized with a
vaccine strain of live, attenuated Salmonella which induces very
high levels of protection against virulent challenge and
concomitant marked immunosuppression.  Although it is not
known if T-cells can protect of suppress, macrophages have been
shown to at least partially mediate both phenomena.  To explore
further the role of T-cells, cloned lines will be developed in vitro
and tested for antigenic specificity and capacity to transfer
Salmonella immunity.  As macrophages have been shown to have
protective and suppressive capacity, subsets of splenic and
peritoneal macrophages from vaccinated and control mice will be
purified and compared, to determine if these activities reside in
the same or different populations.  The cells mediating the
immunosuppression, and the mechanisms involved, will be further
investigated using an in vitro system of antibody formation.
These studies should lead to a better understanding of the
mechanisms of immunity to systemic Salmonella infection and
provide a theoretical framework for development of an improved
typhoid vaccine.

## Key facts

- **NIH application ID:** 3126278
- **Project number:** 2R01AI015613-09
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **SAM.gov UEI:** QD4MGHFDJKU1
- **Principal Investigator:** Toby K. Eisenstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $165,583
- **Award type:** 2
- **Project period:** 1978-12-01 → 1991-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126278

## Citation

> US National Institutes of Health, RePORTER application 3126278, IMMUNITY TO SALMONELLA INFECTION (2R01AI015613-09). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126278. Licensed CC0.

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