# IMMUNITY TO SALMONELLA INFECTION

> **NIH NIH R01** · TEMPLE UNIV OF THE COMMONWEALTH · 1987 · $139,076

## Abstract

Three mouse strains in the C3H lineage, C3H/HeJ, C3HeB/FeJ and
C3H/HeNCr1BR, which differ in their responsiveness of LPS and their innate
susceptibilities to Salmonella infection, will be used to investigate
immunity to Salmonella infection induced by a live, a virulent vaccine
strain, SL3235, that is of a class of mutants being considered for
development of a new vaccine for human typhoid fever.  The mechanisms by
which the vaccine results in specific resistance to virulent Salmonella
infection will be assessed, as will the immunomodulation induced by this
organism.  The degree of macrophage activation to tumoricidal and
microbicidal capacity will be compared with that engendered by killed
Salmonella, BCG and C. parvum.  The role of suppressor macrophages in
modulating the humoral and cellular arms of the immune response will be
investigated, as will molecular correlates of macrophage activation and
suppression as measured by production of PGE-2, IL-1, H202, and 02.  These
studies should provide basic information on immunity to Salmonella
infection, evaluate the potential of SL3235 as an immunomodulating agent,
and possibly provide insight into the nature of the defect in macrophages
of C3H/HeJ mice.

## Key facts

- **NIH application ID:** 3126282
- **Project number:** 5R01AI015613-08
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **SAM.gov UEI:** QD4MGHFDJKU1
- **Principal Investigator:** Toby K. Eisenstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1987
- **Award amount:** $139,076
- **Award type:** 5
- **Project period:** 1978-12-01 → 1988-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126282

## Citation

> US National Institutes of Health, RePORTER application 3126282, IMMUNITY TO SALMONELLA INFECTION (5R01AI015613-08). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126282. Licensed CC0.

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