# CHEMICAL & SEROLOGICAL STUDIES OF LYMPHOCYTE SURFACES

> **NIH NIH R01** · DANA-FARBER CANCER INST · 1988 · $141,633

## Abstract

During the present grant period we propose to carry out studies in
3 areas relating to proteins expressed on the surface of human T
cells:

1)  Human T Cell Receptors.  The expression of both TCR alpha
beta and TCR gamma delta will be studied using cloned genes
encoding the various chains of these receptors.  Some aspects of
the cell biology and functions of these receptors will be examined.
The ultimate goal is to engineer these genes in order to produce
soluble TCR alpha beta and TCR gamma delta, to produce these
soluble receptors in large amounts and to crystallize them.

2)  Pulmonary sarcoidosis.  A primary goal is to culture and clone
the T cells from bronchoalveolar lavage of patients with this
disease with a view to characterizing them phenotypically and
functionally.  In particular we wish to examine the question of
whether or not these T cells are oligoclonal and utilize one or a
small number of T cell receptor alpha and beta gene V, D and J
segments.

3)  The 4F2 protein.  This heterodimeric protein is the first
activation antigen detected on the surface of human T cells.  We
wish to complete the cloning of the genes of this protein and use
them to study the mechanism of activation of their transcription
and their role in cell proliferation.

## Key facts

- **NIH application ID:** 3126338
- **Project number:** 2R01AI015669-11
- **Recipient organization:** DANA-FARBER CANCER INST
- **SAM.gov UEI:** DPMGH9MG1X67
- **Principal Investigator:** JACK L STROMINGER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 1988
- **Award amount:** $141,633
- **Award type:** 2
- **Project period:** 1978-08-01 → 1993-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/3126338

## Citation

> US National Institutes of Health, RePORTER application 3126338, CHEMICAL & SEROLOGICAL STUDIES OF LYMPHOCYTE SURFACES (2R01AI015669-11). Retrieved via MORVS 2026-10-25 from https://api.morvs.ai/grant/nih/3126338. Licensed CC0.

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